Important Safety Information  |  Full Prescribing Information
  • Text Size  A | A | A
  • Readily Available. Order Today.

    FUSILEV is readily available today

    Inconsistent supply of d,l-leucovorin continues

    • Leucovorin supply issues have not been fully resolved in over 48 months—since December 20081
    • Several leucovorin manufacturers continue to report suspended manufacturing, delays, and inability to produce to demand2
    Results from American Hospital Association survey on drug shortages Click image to enlarge

    FUSILEV is readily available with consistent supply

    FUSILEV is readily available today.

    FUSILEV is available through major distributors

    Indications and Usage

    FUSILEV is a folate analog indicated for:

    • Rescue after high-dose methotrexate therapy in osteosarcoma.
    • Diminishing the toxicity and counteracting the effects of impaired methotrexate elimination and of inadvertent overdosage of folic acid antagonists.
    • Use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer.

    Limitations of Use

    • FUSILEV is not approved for pernicious anemia and megaloblastic anemias. Improper use may cause a hematologic remission while neurologic manifestations continue to progress.

    Important Safety Information


    • FUSILEV is contraindicated for patients who have had previous allergic reactions attributed to folic acid or folinic acid.

    Warnings and Precautions

    • Due to Ca++ content, no more than 16 mL (160 mg) of levoleucovorin solution should be injected intravenously per minute.
    • FUSILEV enhances the toxicity of fluorouracil.
    • Concomitant use of d,l-leucovorin with trimethoprim-sulfamethoxazole for Pneumocystis carinii pneumonia in HIV patients was associated with increased rates of treatment failure in a placebo-controlled study.

    Adverse Reactions

    • Allergic reactions were reported in patients receiving FUSILEV.
    • The most common adverse reactions (>50%) in patients with advanced colorectal cancer receiving FUSILEV in combination with 5-FU were diarrhea, nausea and stomatitis.
    • Vomiting (38%), stomatitis (38%) and nausea (19%) were reported in patients receiving FUSILEV as rescue after high-dose methotrexate therapy.

    Drug Interactions

    • FUSILEV may counteract the antiepileptic effect of phenobarbital, phenytoin and primidone, and increase the frequency of seizures in susceptible patients.

    Please click here to see full Prescribing Information for FUSILEV.

    1. U.S. Food and Drug Administration (FDA). FDA current drug shortages. http://www.fda.gov/Drugs/DrugSafety/DrugShortages/ucm314741.htm#leucovorin. Updated December 17, 2012. Accessed December 20, 2012.
    2. American Society of Health-System Pharmacists (ASHP). Current drug shortage bulletin: Leucovorin calcium injection. https://www.ashp.org/DrugShortages/Current/bulletin.aspx?id=488. Updated December 18, 2012. Accessed December 20, 2012.
    3. AHA survey on drug shortages. American Hospital Association Web site. http://www.aha.org/research/index.shtml. Published July 12, 2011. Accessed December 20, 2012.