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What is a folic acid antagonist?
A folic acid antagonist is a type of chemotherapy drug that is used to block the ability of some types of cancer cells from using folic acid to make (replicate) DNA. Because these drugs interfere with cell division, folic acid antagonists attack rapidly dividing cells, including both cancer cells and healthy tissue. Folic acid antagonists include methotrexate, pemetrexed, and trimetrexate.
How is FUSILEV used in accidental folic acid antagonist overdosage?
Rescue with FUSILEV should begin as soon as possible after an accidental overdosage of a folic acid antagonist. The doctor will need to have the levels of methotrexate in the body monitored carefully, such as through blood sampling and other types of tests, and will use this information to determine how to best give FUSILEV under the given circumstances.
